Real-time Raman system for in vivo disease diagnosis

Jason T. Motz; Saumil J. Gandhi; Obrad R. Scepanovic; Abigail S. Haka; John R. Kramer Jr.; Ramachandra R. Dasari; Michael S. Feld

doi:10.1117/1.1920247

1 March 2007 Real-time Raman system for in vivo disease diagnosis

Jason T. Motz, Saumil J. Gandhi, Obrad R. Scepanovic, Abigail S. Haka, John R. Kramer Jr., Ramachandra R. Dasari, Michael S. Feld

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Journal of Biomedical Optics, Vol. 10, Issue 3, 031113 (March 2007). https://doi.org/10.1117/1.1920247

Abstract

Raman spectroscopy has been well established as a powerful in vitro method for studying biological tissue and diagnosing disease. The recent development of efficient, high-throughput, low-background optical fiber Raman probes provides, for the first time, the opportunity to obtain real-time performance in the clinic. We present an instrument for in vivo tissue analysis which is capable of collecting and processing Raman spectra in less than 2 s. This is the first demonstration that data acquisition, analysis, and diagnostics can be performed in clinically relevant times. The instrument is designed to work with the new Raman probes and includes custom written LabVIEW and Matlab programs to provide accurate spectral calibration, analysis, and diagnosis along with important safety features related to laser exposure. The real-time capabilities of the system were demonstrated in vivo during femoral bypass and breast lumpectomy surgeries. Such a system will greatly facilitate the adoption of Raman spectroscopy into clinical research and practice.

©(2005) Society of Photo-Optical Instrumentation Engineers (SPIE)

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Jason T. Motz, Saumil J. Gandhi, Obrad R. Scepanovic, Abigail S. Haka, John R. Kramer Jr., Ramachandra R. Dasari, and Michael S. Feld "Real-time Raman system for in vivo disease diagnosis," Journal of Biomedical Optics 10(3), 031113 (1 March 2007). https://doi.org/10.1117/1.1920247

Published: 1 March 2007

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KEYWORDS

Raman spectroscopy

Tissues

In vivo imaging

Data acquisition

Calibration

Tissue optics

Diagnostics

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